Where to begin? First let us clarify! The virus itself is known as SARS-CoV-2. The disease that may result in having symptoms related to this virus is known as Covid19. SARS- CoV-2 is part of a large family of corona viruses that cause mild to moderate upper respiratory tract illnesses. For Covid19 the data to date shows that eighty percent of infections are mild, fifteen percent can be severe infections and five percent are critical.
In order to enter the host cell the virus appears to gain entry via the ACE2 receptor which is an enzyme present on the epithelial cells on the surface of many cells in the body and are abundant in the lungs. Once the virus docks at the surface of the cell it is dependent on transmembrane serine protease 2 (TMPRSS2) which is a cell surface protein expressed by epithelial cells of specific tissues including those of the aerodigestive tract, for viral activation and cell entry. Cells expressing TMPRSS2 show increased activation and replication of the virus. If TMPRSS2 can be blocked then we can inhibit the activation of the virus. Sulforaphane a compound found in broccoli and other cruciferous vegetables had been found to block TMPRSS2 and decreases its expression. The green tea extract EGCG has also been shown to reduce the secretion of TMPRRS2. There are a number of natural products that have been shown some ability to target ACE2, and these include Andrographis, Nettle, Sambucus and Astragalus as can be seen from the DataPunk Covid 19 Antiviral Database.
The mineral Zinc is involved in many cellular processes and in solution it is in its ionic form Zn++ and it is in this form that it is a decidedly antiviral mineral. High intracellular concentrations stop the replication of RNA viruses of which SARS-CoV-2 is one. It does this by blocking RNA -dependent RNA polymerase which is the main enzyme the viruses use for copying the viral RNA leading to replication. However, cells are not really interested in high levels of Zn++ and do not allow easy entry to the mineral. Something is needed to encourage its entry. There are molecules that will do this known as ionophores. Quercetin and Hydroxychloroquine are both ionophores and escort Zn++ into the cells where it can block virus replication. Green tea EGCG has also shown to be an ionophore. Both Quercetin and Zinc are being tested as antivirals in clinical trials for the treatment of Covid19.
In order to replicate the virus requires that the endosome in which it is encased in the cell, has an acid (low) pH so raising the pH of the cell to alkaline (high pH) will inhibit replication. Hydroxychloroquine in an alkaline drug and will accomplish this. With regard to the recent studies printed in the Lancet and The New England Journal of Medicine regarding the dangers of the drug Hydroxychloroquine claiming that it was extremely dangerous proved to be unfounded as the dosages used in the trial were extremely excessive at 2400mg per dose whereas the normal dose regularly used is 200mg. Both publications retracted the studies, a fact not well publicized! Nettle root has recently come to the fore and has been involved in studies pertaining to its ability to interfere with the replication cycle of the virus.
There are many studies that are ongoing concerning the maze of information and research concerning SARS-CoV-2. At this point I do not wish to get into the politics of the situation which seems to be contributing to the white noise that intimidates us all. Remember that good health is paramount to protecting ourselves against all the viruses and infections out there. It is up to the individual to do the research into all the different available remedies and make the decisions about their health. Our aim is to assist you in your search and giving you the information concerning recent studies pertaining to the science. One truly valuable website where I find a lot of my information is dadamo.com. I have read study after study relating to Covid19, too many to cite here, but I do recommend you visit this site and inform yourself!
Written by: Nathalie McNeill, owner of Fountain Head Health Food Store